Upon enabling two-factor authentication, when trying to open Outlook  you get the following error

Invalid Request: The request Tokens do not match the user context.

This is due to your existing password conflicting.

If you close down outlook

Open up command prompt and enter :   control /name Microsoft.CredentialManager

Clear out MicrosoftOfficeXX_Data:ADL and  MicrosoftOfficeXX_Data:ordid password

Start Outlook again